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Oral hairy leukoplakia OHL is usually asymptomatic, and the unexpected esthetic appearance often alerts an individual to its presence. Rarely, patients complain of mild burning or pain, especially with eating or drinking. Look for known immune suppression or risk factors such as human immunodeficiency virus HIV infection or organ transplantation. Lesions may resolve and recur spontaneously, especially in situations of immune restoration. Exam reveals white or gray adherent cannot be scraped off easily plaques, commonly on the bilateral sides of the tongue Figure 1.
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Oral Hairy Leukoplakia

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Oral Hairy Leukoplakia | Cedars-Sinai

Dennis M. Walling, Catherine M. Flaitz, C. The clinical, histopathological, and molecular viral responses to treatment were assessed in surgical biopsy specimens obtained before, during, and after treatment. In many cases, the initial response to inhibition of replication was a persistent, nonproductive, EBV infection of the oral mucosa, characterized by limited expression of replicative EBV genes, especially BZLF1. In some cases, productive EBV replication recurred after discontinuation of treatment with valacyclovir. In a few treated cases, treatment failed, and productive EBV replication persisted, possibly because of the evolution of acyclovir-resistant EBV.
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It causes white patches on your tongue. Sometimes the patches happen in other parts of your mouth. The patches may look hairy. This is where the name comes from. Oral hairy leukoplakia happens most often in people with weak immune systems.
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It is rare in HIV-negative patients, but has been reported in patients who use immune-modulating medications e. The objectives of this study were to determine the occurrence of OHL in HIV-negative patients and report Langerhans cell counts in these lesions. Langerhans cells were counted using an immunoperoxidase stain for CD1a and light microscopy. Results: The 7 patients were male, ranging in age from 26 to 69 years. Clinically, all lesions were diagnosed as leukoplakia on the lateral border of the tongue.
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